MOTS-C 10MG

MOTS-c is a 16-amino-acid peptide encoded in mitochondrial rather than nuclear DNA, with the molecular formula C101H152N28O22S2, a molecular weight of about 2,174.6 g/mol and the CAS number 1627580-64-6. Its name stands for mitochondrial open reading frame of the 12S rRNA type-c: the instructions for it sit inside MT-RNR1, the gene for a piece of the mitochondrion's own ribosome, a stretch of DNA long assumed to code for RNA only. It was discovered in 2015 by a team at the University of Southern California's school of gerontology, and it belongs to a small family of mitochondrial-derived peptides identified only in the last two decades or so. That origin is the point: it is a signal the mitochondria send to the rest of the cell, and to the nucleus, about energy status. It is commonly researched for its role in cellular metabolism, covering insulin signalling, glucose handling by skeletal muscle and fat metabolism, with the energy-sensing enzyme AMPK at the centre of the proposed mechanism, and for the overlap between the pathways it acts on and those switched on by exercise, which is where much of the current interest sits. Ageing and metabolic-stress models are further lines of inquiry. The evidence so far comes mostly from cells and mice, and robust human data are lacking. It is not approved for any medical use, and the World Anti-Doping Agency has listed it by name as a prohibited metabolic modulator since 2024. Supplied as 10mg of freeze-dried powder per vial, for reconstitution with bacteriostatic water; store at 2–8°C.

Often ordered alongside it